Ryanair is to close its base at Glasgow Airport, warning that 300 undertakings could go as a result.
The airline, which also operates out of Prestwick, Edinburgh and Aberdeen, will cut the number of roads out of Glasgow from 23 to just three.
Chief commercial policeman David O’Brien blamed the change on the cost of air passenger duty and said Glasgow “simply could not bear the burden”.
Glasgow Airport said it was “bitterly disappointed” by Ryanair’s decision.
A spokesman for the airport said there was “no doubt” that the failure to replace air passenger duty( APD) with a cheaper air departure tax( ADT) in Scotland was behind the move.